“Vitamin M” — is melatonin the cure for your sleep problems?

overhead view of a bottle of melatonin supplements on its side lying next to a pile of pills and a sleep mask

If you are noticing that melatonin supplements seem to be taking up more and more space on your drugstore shelves, or seeing more advertisements on your television for products containing melatonin that promise a great night of sleep, you’re probably right. The Centers for Disease Control and Prevention (CDC) estimates that 70 million Americans suffer from chronic sleep problems. For some of these poor sleepers, melatonin is believed to be a safe treatment option for sleep disturbances, because it is a hormone that is naturally produced by our bodies.

How common is melatonin use in the United States?

To answer this question, a team of researchers examined data from the National Health and Nutrition Examination Survey (NHANES). NHANES is an effort led by the CDC that began in the early 1960s. They survey roughly 5,000 Americans each year, from all around the country. The researchers investigated self-reported melatonin use within the past 30 days. NHANES interviewers were shown the melatonin container to prove they were taking the supplements in 93.9% of study participants who reported melatonin use. Recently published findings in JAMA noted that in 1999, 0.4% of adults (20 years of age or older) reported using melatonin. In 2017 this number more than quadrupled, to 2.1% of adults using melatonin.

Is melatonin safe?

For short-term use, melatonin use is considered fairly safe for adults. People typically can expect mild adverse effects, such as dizziness, drowsiness, or a headache. It is also possible that melatonin supplements can interact with several medications, including those prescribed for birth control and diabetes. It is important to note that studies involving melatonin are typically conducted in formal research settings, where the purity and dosage of the supplement are verified.

For consumers who purchase melatonin at their local pharmacy or grocery store, there is reason for caution. Melatonin is considered a dietary supplement by the FDA, not a prescription drug. This is different from countries like the United Kingdom, where melatonin is prescribed. In the US, the manufacture of prescription pharmaceutical products is regulated by the FDA, with clear standards for consistency and quality assurance. While melatonin manufacturers and distributors are expected to meet FDA standards, there is not a systematic process to ensure that the melatonin you purchase is exactly what it claims to be.

In 2017, researchers from the University of Guelph systematically analyzed 31 melatonin supplements that were purchased from local stores. What they uncovered was troubling: compared to the label on the bottle, melatonin content varied from 83% less than what was written, all the way up to 478% more than what was labeled. The researchers explained that they anticipated some samples may have decreased melatonin content because of known degradation and stability issues, but they struggled to explain why so many samples had more melatonin.

Why do pediatricians sometimes recommend melatonin for children?

Melatonin is sometimes viewed as an appealing option for families with children under the age of 18, because there are no FDA-approved pediatric medications for insomnia. In fact, in a 2012 national survey, it was the second most commonly used non-vitamin/non-mineral dietary supplement among 4-to-17-year-olds in the US. Studies have shown that there are some pediatric groups who may benefit from supplemental melatonin, including children with autism spectrum disorders. However, it is noted that there is not enough data available on the safety of long-term melatonin in children.

When should adults use melatonin?

The American Academy of Sleep Medicine (AASM) has recommended that strategically-timed melatonin be used in the treatment of

  • delayed sleep/wake phase disorder in children and adults (without medical or psychiatric comorbidities)
  • blind adults with non-24-hour sleep/wake disorder
  • irregular sleep/wake disorders in pediatric populations with neurologic disorders.

Perhaps just as important as what the AASM has recommended melatonin for is what the organization has recommended melatonin not be used for: insomnia in adults. They found that the quality of the studies assessing melatonin efficacy was low, and there was not consistent data suggesting that it was very effective at improving sleep.

What’s the take-home message?

In the context of sleep, the use of melatonin supplements plays an important role as a chronobiotic (a drug that shifts biological rhythms) rather than as a soporific agent — a drug designed to induce sleep, like zolpidem (Ambien). The prevalence of melatonin use greatly exceeds the data demonstrating that it is effective for the sleep disorder that people often use it for: insomnia. It is important that people struggling with their sleep first consult with their doctors, and consider seeing a sleep expert, before making any decisions about sleep medications or over-the-counter supplements such as melatonin.

Poor housing harms health in American Indian and Alaska Native communities

A scattering of housing on American Indian tribal land in Monument Valley; blue skies with fluffy clouds and red rocks in background

Robbed of ancestral lands, American Indian and Alaska Native tribal communities face an unparalleled housing crisis that pleads for national housing reforms. As victims of centuries of intentional government policies to remove and reallocate lands and resources, many live in third-world conditions that have led to sky-high rates of health problems, ranging from diabetes and cardiovascular disease to chronic liver disease, obesity, unintentional injuries, substance use disorders, violence, and suicides. This paves a path to extremely high rates of disability and prematurely shortened lives.

Poverty and poor housing harm health and drive disability

The stark reality of poverty became obvious when I traveled to my reservation home in Mescalero, New Mexico as a child. There I saw discolored, fractured, or weather-tattered homes, and yards littered with old, rusted, and abandoned cars. According to the National Congress of American Indians, substandard housing makes up 40% of on-reservation housing compared to just 6% of housing outside of Indian Country. On reservations, almost one-third of homes are overcrowded.

In 2019, an estimated 20% of American Indian and Alaska Native people lived in poverty compared to an 11% national poverty rate. Poverty, low education levels, and harsh conditions mean that many American Indians and Alaska Natives lack the foundation for basic survival: stable, secure, adequate, affordable housing.

As historian Claudio Saunt so eloquently wrote, an “invasion” of approximately 1.5 billion acres occurred in the United States from 1776 until the present. This loss of traditional homelands has had devastating, lifelong effects on housing and living conditions. Poor health outcomes soared among the millions displaced over the past 300-plus years.

Today, as a result of poor housing conditions, American Indians and Alaska Natives struggle from environmental ills that include lead exposure, asthma from poor ventilation, infectious diseases due to contaminated water, sanitation issues, and overcrowding. Mental distress is common. Exposure to pollutants raises risk for lung disease, cardiovascular events like heart attack and stroke, and many other illnesses.

Disability and housing

American Indians and Alaska Natives have disability rates 50% higher than the national average, and among people ages 55 and older mobility and self-care disability rates are especially high. Housing that is old, in poor repair, or crisscrossed with physical barriers may not be accessible for many people, preventing them from living independently within their homes and participating fully in community life. This can cause isolation and exacerbate distress and despondency. In addition, unreliable electricity could pose life-threatening risks to people with disabilities requiring ventilator support, and threaten the safety of power wheelchair users (wheelchair batteries must be kept well-charged).

Fair housing feeds health equity

Housing is a well-known contributor to health outcomes and a meaningful lever for health equity. Despite the United States’ promise to assume responsibility for housing and health for American Indians and Alaska Natives in exchange for billions of acres in conceded land, little has been done to achieve positive change. Outsiders may assume that Indians are getting rich from tribal casinos, but that is far from the truth. Many tribes do not have casino revenue. Those who do often struggle to break even, with any earnings canceled out by their tribe’s needs.

Conditions on tribal lands sadly reveal the consequences of historical trauma, poverty, and insufficient federal government support. Each sovereign nation must create sustainable housing projects for its members as determined by its tribal government and housing departments. Federal support varies depending on tribal financial status, resources, and competition from bordering communities.

Seeking national support for these measures could go far:

  • The most viable way of improving environmental conditions on American Indian and Alaska Native lands is through Congress and the Native American Housing Assistance and Self-Determination Act (S.2264). This act provides guaranteed, inflation-adjusted funding to our nation’s tribal communities. All of us can lobby Congress to reauthorize this Act through 2032 by contacting our congressional representatives. Funding from this Act has been available for years, but the meager increases have not matched inflation rates.
  • Tell Congress and state representatives that new housing on tribal lands must support health through structural features such as good ventilation and temperature controls, reliable and clean water throughout, and eliminating barriers that impede access into and within the home. Given high disability rates of American Indians and Alaska Natives, housing must be designed to support independent living needs of all residents. Following universal design principles in developing new housing benefits people of all ages and abilities by acknowledging changes that can occur over a lifespan.

The US government has a moral obligation to ensure that American Indians and Alaska Natives are allowed to acquire lost tribal lands, and afforded the best housing possible to be successful, join fully in community life, and remain healthy. Last year the US Interior Department reauthorized the regional directors of the Bureau of Indian Affairs to review and approve applications to place land into trust. This represents one important step forward, though hopefully not the last.

Sex, drugs, and depression: What your doctor needs to know

young woman talking to her female doctor in a medical clinic setting, anatomy posters are visible on the wall behind her

For many of us, a trip to the doctor’s office produces anxiety: What do my blood results mean? Will my doctor think this bump is cancer? The physical exam can make us feel vulnerable and may involve mild discomfort, so we may shower, shave, and put on better-than-average clothes before heading out for our physical in an attempt to minimize this discomfort.

However, it’s the intimate discussions — whether a crushing depression, escalating alcohol use, or sexual problems — when our palms really start to sweat. These difficult discussions can be more comfortable and productive when we know what to expect.

Sex

Most people do not volunteer their sexual history, so be prepared for your doctor to ask you a few questions directly as part of your comprehensive exam. Doctors ask all patients about their sexual history, regardless of age, gender, and marital status. (This blog post has some tips for talking about sex with your doctor if you are in the LGBTQ+ community.)

As a psychiatrist, I routinely discuss sexual activity with my patients, as changes in mood, substances, and many medications can affect sexual functioning. For example, the most commonly prescribed class of antidepressants, the selective serotonin reuptake inhibitors (SSRIs), are more likely to lower libido than to treat depression. (They achieve remission in approximately 30% of patients — but they cause sexual dysfunction in 60% to 70%.)

What your doctor may ask: The five Ps: partners (number and gender), practices (what kind of sexual contact), protection (method of contraception), past history of sexually transmitted infections (STIs), and pregnancy. Your doctor may also ask about medications or supplements that can affect libido.

What your doctor needs to know: Your doctor needs to understand your risk of getting an STI, including any risky behaviors or substance use. In addition, your doctor needs to hear about any changes in libido, problems achieving orgasm, difficulties maintaining an erection, or a delay in ejaculation. This information helps your doctor think through contributing causes, including your hormone levels, medical conditions, and medications.

Substance use

This is another tricky topic, as almost everyone minimizes their substance use. Most people understand that smoking or excessive alcohol is not good for them — it’s not a matter of education. In fact, patients may avoid revealing their use because they don’t want their doctors to “educate” them.

People using substances often experience shame, one of the strongest negative emotions we can feel, and something people go to great lengths to avoid. It’s helpful to remember the role of your doctor: it’s not to judge, and certainly not to reprimand. Assuming you trust your doctor, it can help to think of your doctor as an ally. Together you can brainstorm ways to decrease use (harm reduction) or to discontinue use altogether, when you are ready.

What your doctor may ask: It is standard practice to ask about tobacco, alcohol, and illicit drug use. If you drink alcohol, smoke, or use substances, be prepared for your doctor to ask detailed questions about the quantity, frequency, attempts to cut down, and cravings.

What your doctor needs to know: The truth! Try to think about the past week and count the total drinks/cigarettes/pills consumed. Also let your doctor know whether you are interested in cutting down or discontinuing use altogether. Your doctor can work with you to optimize your treatment, whether it’s medications to reduce your cravings or connecting you to support groups.

Mental health

Most primary care clinics routinely screen all patients for depression, and some may screen for anxiety disorders as well. If you screen positive, your doctor will almost certainly ask you more questions about your mood, whether you are experiencing anxiety, and even whether you have experienced hallucinations or paranoia. This is not because your doctor thinks you’re crazy; rather, these symptoms may accompany severe illness and could affect treatment decisions.

What your doctor may ask: To assess for depression, your doctor will ask about your sleep, appetite, interest in activities, feelings of guilt, and any changes in concentration or energy level. Your doctor will also ask whether you have experienced thoughts about ending your life. These questions can feel probing and intimate — especially if you came to the doctor’s office for an unrelated complaint, such as heartburn. However, your doctor is asking these questions to develop a better understanding about the length and severity of your symptoms in order to make the correct diagnosis. Here too, it’s helpful to think about your doctor as an ally. If you’re worried about this information going into your medical record, you can request this information to be marked as sensitive. No one is allowed to see your medical records without your permission, unless they are caring for you.

What your doctor needs to know: Sometimes depressed mood and anxiety can be related to an underlying medical illness such as heart, lung, or thyroid problems. Mention any physical symptoms you have noticed, even if they seem unrelated. If this is your first episode of feeling anxious or depressed, think about any life events that could be contributing (such as a recent break-up, job loss, or move), as this may help your doctor in differentiating between an adjustment disorder and a major depressive episode. Talk about your coffee habits and alcohol use, which can affect sleep and anxiety.

The bottom line

Sharing the most intimate details of your life with your doctor is understandably nerve-racking. Rest assured your doctor will keep this information confidential, unless there is a risk you could seriously harm yourself or others. It helps to realize that doctors talk about sex, substances, and mental health with almost all of their patients, and they will meet you where you are. Try to relax, take a deep breath, and remember: the doctor is on your side.

Sexual fluidity and the diversity of sexual orientation

Fluid rainbow colors in an abstract design; concept of fluidity

Who are you today? Who were you a decade ago?  For many of us, shifts in our lives — relationships, jobs, friendships, where we live, what we believe — are the only constant. Yet it’s a common misconception that sexual orientation develops at an early age and then remains stable throughout one’s life.

Rather, changes in sexual orientation are a common thread in many people’s lives. People may experience changes in who they are attracted to, who they have sex with, and which labels they use to describe their sexual orientation. Such changes in sexual orientation are called sexual fluidity.

Attraction, identity, and behavior

While anyone can experience changes in their sexual orientation, sexually fluidity is more common in younger people and among people who are LGBTQ+ (lesbian, gay, bisexual, transgender, queer, and additional identities).

Sexual fluidity might include

  • changes in attractions: Someone may be attracted to one gender at one time point and attracted to a different gender or more than one gender at another time point.
  • changes in identity labels: Someone may identify as lesbian at one time point and as bisexual at another time point.
  • changes in sexual behavior: Someone may have a sexual partner at one time point who is a cisgender woman and then have another sexual partner at a different time point who is nonbinary. (A cisgender woman is a person assigned as a female at birth and who identifies as a woman. Someone who is nonbinary was assigned either female or male at birth and identifies as neither a woman nor a man.)

Sexual fluidity happens for many different reasons. For some people, sexual fluidity occurs when they meet people and discover new attractions. For other people, sexual fluidity may occur when they learn a new identity label that better fits their experience.

Misconceptions and stigma about sexual fluidity

Many people may have questions and biases about sexual fluidity. Let’s explore a few.

Are people who identify as bisexual sexually fluid? Some are and others are not. Sexual fluidity is distinct from bisexuality. Sexual fluidity may be experienced by people with any sexual orientation identity, including people who identify as bisexual, lesbian, gay, or heterosexual.

Stigma directed at sexual fluidity (and similar stigma surrounding bisexuality) may stem from misconceptions about changes in sexual orientation. Consciously or unconsciously, some people may believe that anyone who experiences changes in their sexual orientation is promiscuous or incapable of being monogamous. However, such beliefs are untrue.

Misconceptions and stigma can hurt. Growing evidence links different forms of stigma experienced by people who are sexually fluid with more depression and poor mental health. Yet it’s not the change in sexual orientation that raises this risk, nor is it automatic, genetic, or otherwise predestined. The higher risk of mental health concerns among people who experience sexual fluidity is more likely to be related to minority stress — that is, because sexual fluidity is stigmatized, people who experience that stigma may also experience stress that negatively affects their mental health.

Changing misconceptions and stigma about sexual fluidity

We can help normalize sexual fluidity in several ways. First, we can introduce the possibility of changes in sexual orientation as part of sex education in schools and in the doctor’s office. Second, we can work toward responding to sexual fluidity with openness and curiosity rather than making assumptions and viewing these changes as negative. Third, we can move beyond preconceived notions of sexual orientation as stable to expecting change in sexual orientation for some people.

As people experience the world and learn more about themselves, their views, beliefs, and feelings may change. Sexual fluidity reflects one possible change over time, a change that fits into the greater diversity of sexuality. We can all hold space for this diversity by letting go of misconceptions about the stability of sexual orientation over a lifespan and staying open instead to the possibility of change.

Anti-inflammatory food superstars for every season

Healthy fruits and vegetables including anti-inflammatory superstars

Berries and watermelon in the summer, kale and beets in the winter. The recipe for anti-inflammatory foods to enjoy can change with the seasons.

Your heart, your brain, and even your joints can benefit from a steady diet of these nutritious foods, and scientists think that their effects on inflammation may be one reason why.

Inflammation: How it helps and harms the body

Inflammation is part of your body’s healing mechanism — the reason why your knee swelled and turned red when you injured it. But this inflammatory repair process can sometimes go awry, lasting too long and harming instead of helping. When inflammation is caused by an ongoing problem, it can contribute to health problems. Over time, inflammation stemming from chronic stress, obesity, or an autoimmune disorder may potentially trigger conditions such as arthritis, heart disease, or cancer. It may also harm the brain. Researchers have found a link between higher levels of inflammation inside the brain and an elevated risk for cognitive decline and impairment. Regularly adding anti-inflammatory foods to your diet may help to switch off this process.

Three diets that emphasize anti-inflammatory patterns

Research hasn’t looked specifically at the anti-inflammatory benefits of eating foods that are in season. “But it’s generally accepted that eating what’s in season is likely to be fresher and obviously there are other benefits, including those for the environment,” says Natalie McCormick, a research fellow in medicine at Harvard Medical School. Eating foods that are in season may also help your grocery bill.

When it comes to anti-inflammatory foods, the goal should be to incorporate as many as you can into your overall diet. “Our emphasis now is on eating patterns, because it seems that interactions between foods and their combinations have a greater effect than individual foods,” says McCormick.

Three diets in particular, she says, contain the right mix of elements: The Mediterranean diet, the DASH diet, and the Alternative Healthy Eating Index. These diets are similar in that they put the emphasis on foods that are also known to be anti-inflammatory, such as colorful fruits and vegetables, whole grains, legumes, and healthy fats such as olive oil and nut butters. But just as importantly, these diets also eliminate foods — such as highly processed snacks, red meat, and sugary drinks — that can increase levels of inflammatory markers inside the body, including a substance called C-reactive protein.

Mixing and matching different foods from these diets can help you tailor an anti-inflammatory approach that fits your personal tastes, as can choosing the freshest in-season offerings. Whole grains, legumes, and heart-healthy oils can be year-round staples, but mix and match your fruits and vegetables for more variety. Below are some great options by season.

Winter anti-inflammatory superstars

In the cold winter months, think green. Many green leafy vegetables star during this season, including kale, collard greens, and swiss chard. Root vegetables like beets are another great and hardy winter option. Reach for sweet potatoes and turnips. Other options to try are kiwi fruit, brussels sprouts, lemons, oranges, and pineapple.

Spring anti-inflammatory superstars

When the spring months arrive, look for asparagus, apricots, avocados, rhubarb, carrots, mushrooms, and celery, as well as fresh herbs.

Summer anti-inflammatory superstars

Summer is prime time for many types of produce, and you’ll have lots of choices. Berries are a great anti-inflammatory option. Try different varieties of blueberries, blackberries, and strawberries. Go local with marionberries, huckleberries, gooseberries, and cloud berries, which grow in different parts of the US. Also reach for cherries, eggplant, zucchini, watermelon, green beans, honeydew melon, okra, peaches, and plums.

Fall anti-inflammatory superstars

Nothing says fall like a crisp, crunchy apple. But there are a host of other anti-inflammatory foods to try as well, such as cabbage, cauliflower, garlic, winter squash, parsnips, peas, ginger, and all types of lettuce.

Whenever possible, when you choose an anti-inflammatory food try to substitute it for a less healthy option. For example, trade a muffin for a fresh-berry fruit salad, or a plate of French fries for a baked sweet potato. Making small trades in your diet can add up to big health benefits over time.

Screening at home for memory loss: Should you try it?

photo of a senior woman doing an Alzheimer's disease cognitive function self-assessment test at home

It is estimated that worldwide there are more than 55 million people living with Alzheimer’s disease and other causes of dementia, and this number is estimated to rise to 78 million by 2030 and 139 million by 2050. There are simply not enough neurologists, psychiatrists, geriatricians, neuropsychologists, and other specialists to diagnose these individuals with cognitive decline and dementia. Primary care providers will need take the lead.

Although this may sound like the obvious and simple solution, my friends who are primary care providers remind me that they barely have time to do the basics — like blood pressure and diabetes management — and that they have no time to administer fancy cognitive tests. Even a simple test like the Mini-Cog (clock drawing and three words to remember) is too long for them. So how are we going to diagnose the increasing numbers of individuals with Alzheimer’s and other dementias in the next few decades?

A self-administered test can screen for memory loss

In 2010, clinicians at the division of cognitive neurology in The Ohio State University Wexner Medical Center developed a cognitive test to screen for memory loss that individuals can self-administer. This concept of a self-administered cognitive test can solve the problem of the time-crunched primary care provider. Individuals can take this test in the privacy of their own home and bring the results with them to the office. The results can then be used to determine whether additional work up and/or referral to a specialist is indicated.

The test, the Self-Administered Gerocognitive Examination (SAGE), has compared favorably to clinician-administered tests such as the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), as well as to standard neuropsychological testing. What was not known, however, is how well SAGE would be able to predict who would develop Alzheimer’s disease or another cause of dementia.

Predicting the future

To answer this question, the authors performed a retrospective chart review on 655 individuals seen in their memory disorders clinic, with a follow-up of up to 8.8 years. They compared their SAGE test to the MMSE.

Based on both initial and follow-up clinic visits, they divided their clinic population into four groups. Before I describe the groups, let me explain a few terms:

  • Dementia is when cognitive impairment leads to impaired function.
  • Mild cognitive impairment (MCI) is when there is cognitive impairment, but function is normal.
  • Subjective cognitive decline is when individuals are concerned about their thinking and memory, but both cognition and function are normal.

The four groups they compared were individuals with

  • Alzheimer’s disease dementia
  • MCI who converted to Alzheimer’s disease dementia
  • MCI who converted to another type of dementia
  • subjective cognitive decline.

They found a surprisingly high correlation between the SAGE test and the MMSE in being able to predict how each of these groups did over time. Moreover, they found that the SAGE test could predict the conversion of an individual with MCI who would develop dementia six months earlier than the MMSE.

What is needed to bring this test into current practice

Even a self-administered test that individuals can do at home will still require training for primary care providers, to understand how the test should be used and how to interpret the results. There is no question, however, that such training will be worthwhile. Once the training is complete, the knowledge gained should be able to save literally thousands of hours of clinician time, in addition to missed — or improper — diagnoses.

Another question is how individuals will react when they are told that they need to perform a 10-to-15-minute cognitive test at home and bring the results to their doctor. Will they do it? Or will the ones who need the test the most avoid doing it — or cheat on it? My suspicion is that people who are concerned will do the test, as will people who generally follow their doctor’s instructions. Some individuals who would benefit from the information that the test provides may not do it, but many of those individuals wouldn’t do the “regular” pencil-and-paper testing with the doctor or clinic staff either.

A new model of cognitive screening

Previously, there were two types of screening instruments to help determine if someone is developing cognitive impairment that could lead to dementia: clinician-administered cognitive tests and family/caregiver questionnaires. Now there is a third type of screening instrument: a self-administered test. Use of these self-administered tests will be key in detecting the increasing numbers of individuals with Alzheimer’s disease and other causes of dementia who will be with us in the next several decades.

Want to test yourself?

You can download the SAGE test here. As it says on the website, please take the answer sheet to your doctor so they can score it and speak with you about the results.

Save the trees, prevent the sneeze

photo of a man sitting on the ground with his back against a tree holding a tissue to his face and blowing his nose; ground is covered in leaves indicating fall season

When I worked at Greenpeace for five years before I attended medical school, a popular slogan was, “Think globally, act locally.” As I write this blog about climate change and hay fever, I wonder if wiping off my computer that I’ve just sneezed all over due to my seasonal allergies counts as abiding by this aphorism? (Can you clean a computer screen with a tissue?)

Come to think of it, my allergies do seem to be worse in recent years. So do those of my patients. It seems as if I’m prescribing nasal steroids and antihistamines, recommending over-the-counter eye drops, and discussing ways to avoid allergens much more frequently than in the past. Are people more stressed out, working harder, sleeping less, and thus more susceptible to allergies? Or, are the allergies themselves actually worse? Could the worsening of climate change explain why the rates of allergies and asthma have been climbing steadily over the last several decades?

There’s more pollen and a longer pollen season

Seasonal allergies tend to be caused disproportionately by trees in the spring, grasses in the summer, and ragweed in the fall. The lengthening interval of “frost-free days” (the time from the last frost in the spring to the first frost in the fall) allows more time for people to become sensitized to the pollen — the first stage in developing allergies — as well as to then become allergic to it. No wonder so many more of my patients have been complaining of itchy eyes, runny nose, and wheezing.

In many places in the United States, due to climate change, spring is now starting earlier and fall is ending later, which, yearly, allows more time for plants and trees to grow, flower, and produce pollen. This leads to a longer allergy season. According to a study at Rutgers University, from the 1990s until 2010, pollen season started in the contiguous United States on average three days earlier, and there was a 40% increase in the annual total of daily airborne pollen. More recent research in North America shows rising concentrations of sneeze-inducing pollens and lengthening pollen seasons from 1990 to 2018, largely driven by climate change.

Climate change is increasing the potency of pollen

In addition to longer allergy seasons, allergy sufferers have other things to fret about with climate change. When exposed to increased levels of carbon dioxide, plants grow to a larger size and produce more pollen. Some studies have shown that ragweed pollen, a main culprit of allergies for many people, becomes up to 1.7 times more potent under conditions of higher carbon dioxide. With warming climates, the geographic distribution of pollen-producing plants is expanding as well; for example, due to warmer temperatures, ragweed species can now inhabit climates that were formerly inhospitable.

Other unfortunate consequences of climate change, which we are already witnessing, include coastal flooding as the arctic ice sheets melt, causing the sea levels to rise; and more extreme weather, such as storms and droughts. With the increased coastal flooding, mold outbreaks are more common, which can trigger or worsen allergic reactions and asthma. More extreme weather events, such as thunderstorms, are associated with an increase in emergency department visits for asthma attacks. (It is unclear why this is the case, but one theory suggests that the winds associated with thunderstorms kick up a tremendous amount of pollen.) Allergies and asthma are closely associated, with many people, this author included, having “allergic asthma” that is likely to worsen as climate change progresses.

So what can an allergy sufferer do?

Even as the allergic environment changes in conjunction with our climate, there are steps you can take to manage the impact of seasonal allergies and reduce sneezing and itchy eyes.

  • Work with your doctor to treat your allergies with medications such as antihistamines, nasal steroids, eye drops, and asthma medications if needed. If you take other medications that may interact with over-the-counter allergy medications such as Benadryl or Sudafed, let your doctor know.
  • Discuss with your doctor whether you would benefit from allergy testing, a referral to an allergist, or prevention methods like allergy injections or sublingual immunotherapy, which, by exposing your body in a controlled manner, slowly conditions your immune system not to respond to environmental allergens.
  • Track the local pollen count and avoid extended outdoor activities during peak pollen season, on peak pollen days. However, most doctors would agree that it isn’t healthy to cut back on exercise, hobbies, or time in nature, so this is a less than satisfying solution at best. You could plan for an indoor exercise program on high-pollen days.
  • Wash clothing and bathe or shower after being outdoors to remove pollen.
  • Close windows during peak allergy season or on windy days.
  • Wear a mask when outdoors during high pollen days, and keep car windows rolled up when driving.
  • If your house has been flooded, be on the lookout for mold. There are services that you can hire that will inspect your home for mold, and remove the mold if it is thought to be harmful.
  • Have as small a carbon footprint as possible and plant trees. Even though they are responsible for some of the pollen that many of us choke and gag on each spring, summer, and fall, trees contribute to their environment by taking in carbon dioxide and producing the oxygen we breathe, thereby improving air quality. We have to protect and plant trees, even as allergy sufferers, as climate change is arguably the biggest threat that we, as a species, now face.

Overeating? Mindfulness exercises may help

A whiteboard with a drawing of a slice of seeded melon and the words "Mindful eating," "Notice," "Observe," "Feel," "Taste," "Enjoy" written in blue pen, Fingers are holding blue pen. fingers hold a pen

We all experience moments of indulgence that lead to overeating. If it happens once in a while, it’s nothing to worry about. If it happens frequently, you may wonder if you have an overeating problem or “food addiction.” Before you worry, know that neither of those is considered an official medical diagnosis. In fact, the existence of food addiction is hotly debated.

“If it exists, food addiction would be caused by an actual physiological process, and you’d experience withdrawal symptoms if you didn’t have certain foods, such as those with sugar. But that’s a lot different than saying you love sugar and it’s hard not to eat it,” notes Helen Burton Murray, a psychologist and director of the Gastrointestinal Behavioral Health Program in the Center for Neurointestinal Health at Harvard-affiliated Massachusetts General Hospital.

Many people unconsciously overeat and don’t realize it until after they finish a meal. That’s where mindfulness exercises can help you stick to reasonable portion sizes.

But she urges you to seek professional help if your thoughts about eating are interfering with your ability to function each day. Your primary care doctor is a good place to start.

What is mindful eating?

Mindfulness is the practice of being present in the moment, and observing the inputs flooding your senses. At meal time: “Think about how the food looks, how it tastes and smells. What’s the texture? What memories does it bring up? How does it make you feel?” Burton Murray asks.

By being mindful at meals, you’ll slow the eating process, pay more attention to your body’s hunger and fullness cues, and perhaps avoid overeating.

“It makes you take a step back and make decisions about what you’re eating, rather than just going through the automatic process of see food, take food, eat food,” Burton Murray says.

Set yourself up for success in being mindful when you eat by:

  • Removing distractions. Turn off phones, TVs, and computers. Eat in a peaceful, uncluttered space.
  • Pacing yourself for a 20-minute meal. Chew your food slowly and put your fork down between bites.

More mindfulness exercises to try

Practicing mindfulness when you’re not eating sharpens your mindfulness “muscles.” Here are exercises to do that.

  • Focused breathing. “Breathe in and breathe out slowly. With each in breath, allow your belly to go out. With each out breath, allow your belly to go in,” Burton Murray explains. “This engages the diaphragm, which is connected to the nerves between the brain and gut and promotes relaxation.”
  • Progressive muscle relaxation. In this exercise, you tighten and release one major muscle group at a time for 20 seconds. As you release a contraction, notice how it feels for the muscles to relax.
  • Take a mindful walk, even if it’s just for five minutes. “Use your senses to take in your surroundings,” Burton Murray suggests. “What colors are the leaves on trees? Are there cracks on the ground, and where are they? What does the air smell like? Do you feel a breeze on your skin?”
  • Practice yoga or tai chi. Both of these ancient martial arts practices include deep breathing and a focus on body sensations.
  • Keep a journal. Write down the details of your day. Try to include what your senses took in — the sights, sounds, and smells you experienced, and the textures you touched.

Don’t worry about trying to be mindful all day long. Start with a moment here and there and build gradually. The more mindful you become throughout your day, the more mindful you’ll become when you eat. And you may find that you’re better able to make decisions about the food you consume.

Can vitamin D supplements prevent autoimmune disease?

Close up of soft gel vitamin D capsules on a yellow background

You don’t have to look far to find claims that taking vitamin D supplements is great for your health. It’s supposed to be good for everything from preventing cancer and dementia to avoiding infections and heart disease.

Unfortunately, many supposed benefits of vitamin D supplements remain unproven. Yet, millions of people take vitamin D regularly, thinking it will help prevent a wide range of illnesses, including certain autoimmune conditions. But does it? A new randomized, controlled study published in TheBMJ looks closely at that question.

Why would vitamin D prevent autoimmune disease?

Although the cause of most autoimmune disease is largely unknown, the leading theory is that the regulation of the body’s immune system goes awry. The immune system normally defends the body from invaders such as infections, and helps repair damaged tissues. When an autoimmune condition develops, the immune system attacks its host. For example, with rheumatoid arthritis, immune cells attack joints, lungs, and other parts of the body.

Research has shown that vitamin D can interact with immune cells, affect genes that regulate inflammation, and alter the response of the immune system. So it makes sense to investigate whether supplemental vitamin D is an effective way to treat or prevent autoimmune disease.

The BMJ study drew on data gathered during a large trial published several years ago. More than 25,000 older adults were randomly assigned to take

  • 2,000 IU of vitamin D or an identical placebo (inactive pill) daily. (This is higher than the recommended daily amount for adults, but lower than the upper limit of 4,000 IU.)
  • 1,000 mg of omega-3 oil or an identical placebo daily.

After an average of five years, new diagnoses of autoimmune disease among study participants were tallied.

What did the new study find?

The answer may depend on where you heard or read about the BMJ study. It’s true that the researchers found that adults taking vitamin D supplements had a lower risk of developing autoimmune disease. But here’s what some of the more enthusiastic news headlines said:

  • Vitamin D supplements really do reduce risk of autoimmune disease (New Scientist)
  • Taking Vitamin D Daily Can Help Prevent This Disease, New Study Says (Eat This, Not That!)
  • Taking vitamin D and omega-3 fish oil supplements every day cuts your risk of developing arthritis by 22%, study suggests (Daily Mail)

Sounds great, right? But is it true?

What does a closer look at the study tell us?

The researchers reported that

  • 123 people taking vitamin D developed autoimmune disease, compared with 155 people in the placebo group. This represents a 22% reduction. That sounds like a lot, but the actual decrease in risk for developing an autoimmune disease fell from about 12 people in 1,000 to 9.5 people in 1,000.
  • Rheumatoid arthritis, polymyalgia rheumatica, and psoriasis were the most common conditions. No single autoimmune disease was reliably prevented by vitamin D supplementation. Only when the numbers of all the autoimmune diseases were combined did researchers see a benefit.
  • The benefit of vitamin D was more obvious when only the final three years of the study were analyzed. This suggests that it takes a while to benefit from a daily supplement.
  • Those assigned to receive omega-3 fatty acids did not have a lower risk for confirmed autoimmune disease.
  • Side effects were minor and similar in those taking supplements and those taking placebo.

This randomized study is among the best to explore the impact of vitamin D supplementation on the risk of developing autoimmune disease. Yet the study relied on self-reported cases, later confirmed by medical record review. So it’s possible that some cases of autoimmune disease were overlooked.

In addition, the study only included older adults (average age 67). This is important because some of the most common autoimmune diseases, such as lupus and rheumatoid arthritis, typically begin in early adulthood. The results might have been different if the study had included younger participants.

Should we all be taking vitamin D supplements?

Based on this study, I’d say no. For one thing, these findings need to be confirmed by other independent researchers. And despite overly enthusiastic headlines, actual risk reduction was just 2.5 cases out of 1,000. Hundreds of people would need to take vitamin D daily for years to prevent a single case of autoimmune disease. Vitamin D can interact with other medicines, and taking high amounts of vitamin D can be harmful.

The bottom line

Is vitamin D a safe, all-natural wonder drug that can prevent or treat a litany of diseases? Based on current research that’s not clear yet, though I think it’s best to keep an open mind. We may find vitamin D does little for the average person but is highly beneficial for others; the trick is figuring out who is most likely to benefit. For example, perhaps supplemental vitamin D will be especially helpful for people who have a strong family history of certain autoimmune diseases.

Right now, we have the latest chapter in the story of vitamin D. Future research may reveal that a different dose or formulation of vitamin D might be particularly beneficial. Perhaps most importantly, this study and others to come could provide a better understanding of the role of vitamin D in the development of autoimmune diseases.

Follow me on Twitter @RobShmerling

Snooze more, eat less? Sleep deprivation may hamper weight control

Couple asleep in bed with multicolored striped pillow case and quilt, morning light coming through window; one has arm over the other

Weight loss once was considered a simple calculation: eat less and move more to create a calorie deficit. Now, basic differences between people — in genetics, health conditions, body type, and more — are also thought to play a role in how challenging it is to lose weight. Yet research suggests that some factors may help set the stage for success.

Sleep more to eat less? New research boosts this premise, suggesting that adults who are better rested consume significantly fewer calories than those who are chronically sleep-deprived.

This short-term study of 80 overweight people drives home just how integral slumber — or lack of it — is to our propensity to put on excess pounds, says Dr. Beth Frates, director of lifestyle medicine and wellness in the department of surgery at Massachusetts General Hospital.

“Working to find ways to clean up sleep hygiene may help people to extend sleep time to the recommended seven to nine hours per night,” Dr. Frates says. “This could, in turn, lead to consuming fewer calories and even weight loss in people who are in the overweight category by BMI.”

Sleep shortfall linked to chronic diseases

The new study, published in JAMA Internal Medicine, reinforces earlier findings indicating that people who sleep less consume more calories — and even crave higher-calorie foods — compared with those who sleep for longer periods.

About one-third of Americans don’t sleep the recommended seven to nine hours each night, Dr. Frates notes, and this shortfall is linked to many chronic diseases, including high blood pressure, heart disease, diabetes, and obesity. Sleep, she says, is one of the six pillars of lifestyle medicine — a list that also includes exercise, nutritious eating, stress reduction, social connection, and avoiding risky substances.

“Most people focus on exercise and diet when it comes to weight management and a healthy heart, but few focus on sleep,” she says.

Tracking sleep cycles, calories, and weight

The study participants were adults ages 21 to 40 with a BMI between 25.0 and 29.9, which is considered overweight. All of them routinely slept less than 6.5 hours each night. For the first two weeks, all maintained normal sleep patterns.

For the second two weeks, participants were randomly split into two equal groups. With the aim of lengthening sleep times to 8.5 hours, one group received individualized counseling pointing out ways to alter sleep-busting factors relating to bed partner, children, and pets.

“The advice wasn’t generalized,” Dr. Frates notes. “It was specific to the person, and then there was a follow-up visit with more counseling.” The second group of participants continued their typical sleep habits.

All were told to keep up daily routines without changing diet or exercise habits. Each wore a wrist device that tracked their sleep cycles, and they weighed themselves each morning. Sophisticated lab tests teased out the difference between the number of calories each participant consumed and expended each day.

Balancing appetite-regulating hormones

Researchers found participants who received sleep hygiene counseling slept for more than an hour longer each night than those continuing their prior sleep habits. Extended-sleep participants also consumed an average of 270 fewer calories each day and lost about a pound compared to control group participants, who gained just under a pound on average.

The findings are exciting, because they reveal the power of education and counseling on behavior change — in this case sleep, Dr. Frates says. Significant extra slumber time can help people feel like they’re thriving rather than just surviving, she adds.

But why might extra sleep matter? Sleep duration has long been linked to the body’s production of appetite-regulating hormones. Insufficient sleep is associated with higher levels of the hormone ghrelin, which increases appetite, and lower levels of the hormone leptin, which leads to feeling less full. This sets people up to gain weight. By contrast, sleeping more could alter these hormones and bring them back to balance.

“People might also feel more alert, energized, and happier with more sleep,” Dr. Frates adds. “This could lead to more activity, even if it isn’t exercise. It may lead to less sitting and more socializing.”

It’s worth noting that the study didn’t reveal whether the extended sleep pattern was maintained after the two-week intervention period, or what types of food participants ate and when.

The study had other limitations, too. “Were the people in the sleep extension intervention making healthier choices?” Dr. Frates asks. “Calories are important, but what makes up those calories is equally important. Measuring hunger levels, cravings, and stress levels would also provide important information.”

Takeaway tactics to improve your sleep

A few key tactics from the study could help you improve how long you sleep — and possibly help you take in fewer calories:

  • Keep a sleep log
  • Monitor sleep times with wrist actigraphy devices such as smartwatches
  • Evaluate bedtime routines to tweak factors influencing sleep duration
  • Limit use of electronic devices at least an hour before bed.